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Semisynthetic, site-specific ubiquitin modification of -synuclein reveals differential effects on aggregation

This was first demonstrated by finding that chemical inhibition of the neutrophil oxidative burst exhibited PPP and G6PD dependence ( ex vivo ( Figure 1B-1 ): phagocytosis, release of neutrophil extracellular traps (NETs), and degranulation accompanied by rapid production of large amounts of extracellular ROS