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Disruption of this localization, either through reduced perivascular coverage, abnormal distribution, or phosphorylation changes, has been observed in both PD models and patient-relevant studies (Figure 1E

The long-term effects of GLP1s are still being studied, and it is unclear whether patients will need to stay on the medication forever or if they can eventually stop taking it without gaining weight back 8m0s

Although CpG methylation is well-studied, it has been discovered that non-CpG methylation, particularly at CpH dinucleotides (H = A, T, or C), can also occur in specific cell types or stages of development (33)