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When excessive intracellular Ca 2+ causes overloading, a series of Ca 2+ -dependent biochemical reactions, such as mitochondrial dysfunction, are induced, causing hypoxic neuronal injury and diminished memory and learning capacity (Tanovic and Alfaro, 2006)

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Subsequently, the gut microbiota produces short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate, which affect intestinal homeostasis (147, 153)