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This same study found that cerebral vasculature experiences prolonged up-regulation of MHCI and MHCII, following systemic bacterial infection (Puntener et al., 2012), suggesting cells of the vasculature also remain in a primed state

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However, the low negative predictive values for the smartphone images reflect a missed NMSC in about 25% of lesions (42/170) which severely restricts its predictive value for any negative diagnosis of NMSC