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In the case of CBS, the function of the AdoMet-binding regulatory domain appeared less important than the catalytic domain to functional complementation, as variants in this domain were generally more likely to be tolerated in our assay

doi:10.1186/1471-2407-13-334 [9] McGregor B

Elucidating the central role of neuroinflammation and its intricate interactions with age-related pathological processes holds significant theoretical and clinical implications for developing novel neuroprotective strategies targeting CNS symptoms in MG and achieving personalized, precision medicine tailored to patients across different age groups

A., Philips N., Verwijs R., Vanderbeke L., Van Tienen C., et al