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Moreover, the core region of solid tumors exhibits a deficiency of glutamine compared with other amino acids

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In turn, aggregated NPs may increase reactive oxygen species (ROS) generation, alter biodistribution and accumulation sites, and disrupt redox homeostasis in immune cells and tissues

Abnormalities in zinc metabolism leading to its deficiency are generally attributed to various factors like, malabsorption, malnutrition, decreased intestinal zinc binding factors or the increased excretion of the zinc via the gastrointestinal tract or via urine are of common occurrence in chronic liver disorders 35