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Evidence of ADE in coronavirus infections in vitro While ADE has been well documented in vitro for a number of viruses, including human immunodeficiency virus (HIV) 33,34 , Ebola 35,36 , influenza 37 and flaviviruses 38 , the relevance of in vitro ADE for human coronaviruses remains less clear

In experiments involving 25 female volunteers, catalpol applied in the form of lipid nanoparticles demonstrated anti-wrinkle, moisturizing effects, and regeneration of the protective barrier of the stratum corneum ( 6 Novel drug delivery routes However, catalpol is easily degraded in the normal gastrointestinal environment, requiring oral doses several times higher than intravenous administration