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In addition, it has been found that an FXR/TGR5 double agonist (INT-767) can significantly reduce atherosclerotic plaques in ApoE / and LDLR / mice by inhibiting the expression of NF-B [370]

Senolytic agents include natural compounds such as quercetin 13 or fisetin 14 , -galactosidase-activated nanoparticles and prodrugs 15,16,17 or compounds that target different vulnerabilities of senescent cells, such as HSP90 inhibitors 18 , cardiac glycosides 19,20 or NMT inhibitors 21