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However, it has been observed that the c-Abl expression is downregulated in MMR deficient cells

Lee WM (2017) Acetaminophen (APAP) hepatotoxicityisnt it time for APAP to go away

Mice deficient in mdr1a and mdr1b revealed that P-gp knockout was not fatal in mice but likely increased the assimilation and neurotoxicity of various drugs ( mdr1a / mdr1b and mrp1 genes demonstrated that P-gp and MRP1 transporters were responsible for the development of resistance to anthracyclines, taxol, and vinca alkaloids (245)