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alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice

3 Neuropathological changes in HIV-associated depression 3.1 Inflammatory and metabolic dysregulation in HIV-associated depression Neuroinflammatory responses likely play a central role in the neuropathology of HIV-associated depression ( Figure 2 )

Taking into account that reactive astrocytes may produce various neurotrophic factors and antioxidant molecules targeting neuronal survival, it is possible that genetic manipulation of these functions in astrocytes may represent a promising strategy to improve dopaminergic neurons or neural progenitor cells survival [4,23]