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J Pediatr 2013

In Hepa1-6 mouse tumor models, ESPs from A

doi: 10.1126/science.1118370 16 DasS.MallickU.SahuB.TurukJ.SahuM.PandaS

Senescent cells promote inflammation and fibrosis by activating the p16/p21-Rb pathway and secreting senescence-associated secretory phenotype (SASP) factors, including IL-1, IL-6, IL-8, TGF-, plasminogen activator inhibitor (PAI), and insulin-like growth factor-1(IGF-1) (Lin et al., 2022