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This is the International Rulebook. It ensures that trial data is globally credible and, most importantly, that the rights and safety of participants are protected under a unified standard

22,23 We are working to change the perception, awareness, and management of hyperkalaemia to optimise treatment across the full spectrum of cardiorenal diseases and ensure that patients receive internationally recognised guideline-directed treatment and better patient-centric disease management, to improve their outcomes and quality of life

The long-term effects of chronic use on the endocrine system have not been formally investigated

The combination achieved 20.4% mean body weight reduction from baseline to week 68 (22.7% under the trial product estimand that accounts for discontinuation)