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Nevertheless, its infection risk remains low, with no reports of severe opportunistic infections, offering a safety advantage over TNF- inhibitors ( Canakinumab, a monoclonal antibody targeting IL-1, has shown superior efficacy in early trials, with an ACR50 response rate of 26.5% and rapid improvements in DAS28 and HAQ scores ( Long-term administration of IL-1 inhibitors in RA clinical trials primarily manifests as injection site reactions and elevated infection risks

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