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Due to the multiple effects of SARS-CoV-2 that alter cellular metabolic and oxidative states, there are multiple directions to deplete NAD+, loss of cellular ATP and reduced Poly-ADP-ribose polymerase (PARP) activity, each of which have cytotoxic effects of their own [69]

RESULTS: FROM THE PHASE III ELATIVE TRIAL Marcelo Kugelmas 1 Cynthia Levy 2 Nuno Antunes 3 Jianfen Shu 3 valeria Cranham 4 Kris Kowdley 5 , 1 South Denver Gastroenterology, 2 University of Miami, 3 Ipsen, Cambridge, MA, USA, 4 Ipsen, Boulogne-Billancourt, le-de-France, France, 5 Liver Institute Northwest Background: ELATIVE is a phase III study evaluating the efficacy and safety of elafibranor, a dual peroxisome proliferator-activated receptor-/ agonist, in primary biliary cholangitis (PBC), a rare, cholestatic liver disease

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Accelerated Wound Closure & Angiogenesis In injury models, TB-500 has consistently been shown to accelerate wound closure when compared to untreated controls