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Adaptation in the form of optimal folate-related gene epistasis and skin pigmentation would be selected to maintain provision of folate coenzymes for crucial methylation and DNA-thymidylate biosynthetic processes

Cell-mediated immunity plays a central role, with nave CD4 + T cells differentiating into effector subsets upon antigen recognition: Th1 cells secrete IFN-, IL-2, and TNF-, inducing MHC class II expression and promoting Fas-mediated apoptosis of thyrocytes

Mak PY, Mak DH, Kojima K, Dilip A, Ruvolo V, Jacamo R, Andreeff M , Carter BZ

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