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Reach out now with a plan: confirm their current prescription status, discuss alternative formulations (gels, creams, oral options), and establish a compounding pharmacy relationship as a backup if their preferred product remains unavailable

Interestingly, direct fibroblast proliferation as measured by cell assay was not significantly affected, suggesting the mechanism is more nuanced than simple cell replication

NNMT inhibition begins within hours, but measurable changes in NAD+ levels and adipose tissue markers typically require 714 days of consistent dosing

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