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Since the mechanism of induction of tumours by acetaldehyde has not been well studied, two approaches were adopted for the provision of guidance with respect to this end-point, i.e., the development of a tolerable concentration based on division of an effect level for irritancy in the respiratory tract of rodents by an uncertainty factor, and, estimation of lifetime cancer risk based on linear extrapolation

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In addition to its well-established role in apoptosis, the p53 pathway regulates ferroptosis sensitivity (Jiang et al, 2015