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The significance of this consideration has been exemplified by the subset of therapeutics developed to target glycolysis, such as lonidamine, whose clinical success has been arrested due to significant pancreatic and hepatic toxicity 24

NRF2 activators are not restricted to a specific organ or tissue and therefore may exhibit various side effects and disruption of physiological mechanisms

IAV infection has also been shown to suppress glucose-6-phosphate dehydrogenase expression, leading to decreased Nrf2 expression, induction of oxidative stress, and viral replication 70

Selective removal of the violet color produced by anthocyanins in procyanidin-rich unfermented cocoa extracts