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Compared to aforementioned cross-sectional and casecontrol studies, we performed several large populations encompassing over approximately 10,000 NAFLD patients and over 780,000 controls, conducted state-of-art approaches of causal analysis (various MR methods) to minish reverse causality and unobserved confounding impact, and eventually, offered sufficient power to evaluate the causal effect of vitamin B12 concentrations on NAFLD risk