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2C), and no A deposition was observed in WT mice

Hanaoka, K., Sasakura, K., Suwanai, Y., Toma-Fukai, S., Shimamoto, K., Takano, Y

Notably, Brusatol, a natural NRF2 inhibitor, enhances the binding of KEAP1 to NRF2, promotes NRF2 ubiquitination, and accelerates its proteasomal degradation, thereby suppressing NRF2-driven antioxidant function and sensitizing cancer cells to oxidative stress