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Nicotine Addiction The Deadliest And Most Addictive Drug Think before you inhale. Nicotine is highly addictive whether it comes from a cigarette or a vape. While vaping is often marketed as a safer alternative, most nicotine vapes contain New Poll Shows U.S. Adults Find Cigarettes Most Unsafe, Addictive Substance Southern Iowa Mental Health Center Vaping: What Parents Need to Know Vaping isn't harmless it's a serious concern. Most vape products contain nicotine, a highly addictive substance that can impact developing brains and overall health.

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