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While HIF-1 promotes osteoclastogenesis under hypoxia via AMPK signaling (Tang et al., 2020), it also induces apoptosis in osteocytes through the JNK/caspase-3 pathway in vitro , further stimulating osteoclast differentiation by increasing apoptotic bodies (Song et al., 2020)

Mamza, B.K

doi: 10.1016/j.ccell.2017.08.017 5 RyallSZapotockyMFukuokaKNobreLGuerreiro StucklinABennettJet al

Some animal experiments and preliminary clinical studies have shown potential application value in the treatment of heart diseases such as heart failure and myocardial infarction