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Regulatory T cell (Treg) development is also stimulated during hookworm infection ( Figure 1 Increasing Burden of Autoimmune Disease Autoimmunity is the failure of the immune system to distinguish pathogens from self-antigens resulting in damage to healthy tissue ( Dirty Old Friends The hygiene hypothesis, formulated in 1989, proposed that lower intensities of infections during early childhood could explain the emergence of asthma and hay fever later in life ( Concordantly, the old friends hypothesis suggests that various organisms, including helminths and microbiotas, have long coevolved with their mammalian hosts and act as inducers of immunoregulatory circuits ( Animal Models of Helminth Therapy Over the last decades, there have been numerous animal models used to study hookworm therapy for autoimmune disease (IBD, MS, RA, and T1D)

This leads to accumulation of lipid peroxides via the Fenton reaction, ultimately resulting in membrane disruption

It is notoriously known as the king of poisons and poison of kings (Gupta et al., 2017)

Avoid letting it warm up to room temperature during transit.