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164 In addition, hyperglycemia and other metabolic disorders such as dyslipidemia, inflammatory factors, excess IAPP and alterations in the gut microbiota, combine to contribute to IR and/or cell dysfunction through the common pathways of inflammation, ERS and oxidative stress (Fig

Alpha-ketoglutarate dehydrogenase: A target and generator of oxidative stress

As the K4 and SPH domains belong to the and subunits of HGF, respectively, such strong K4/SPH interaction would be important for the structural integrity of HGF / heterodimer in addition to the disulfide bond between these two subunits

Most notably, X-Ray diffraction pattern analysis revealed that the drug loading technique did not impair the material's crystallinity (Kong et al