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PRC2 is thought to get locked on the mutant methionine residue, preventing it from moving along the chromatin to methylate adjacent wild-type histones, which reorganizes the methylation status at H3K27 across the genome with some areas showing loss and others gain of trimethylation. Overall, an altered methylome that has several downstream consequences for DIPG tumors

Reads were counted with HTSeq (v0.11.0)

These reductions were accompanied by reduced species diversity [82]

[DOI] [PMC free article] [PubMed] [Google Scholar] 177.Bondareva AA, Capecchi MR, Iverson SV, Li Y, Lopez NI, Lucas O, Merrill GF, Prigge JR, Siders AM, Wakamiya M, Wallin SL, Schmidt EE