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Recent advances in neuroimaging technology allowing for in vivo quantification of GSH levels in the brain have shown decreased GSH in patients with MS compared to healthy controls, with the degree of depletion correlating with disease severity and showing parallel longitudinal decline over time (Choi et al., 2018

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In the comparative reduction assays with free roGFP1, roGFP1-iL, roGFP2, and roGFP2iL, purified At GRX2 to a final concentration of 2 M was included in the reaction mix