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High K + -induced depolarization amplifies neuroprotection provided by UA through a mechanism involving Ca 2 elevation and extracellular signal-regulated kinases (ERK 1/2 ) activation ( Figure 3 )

General weakness and decreased activity, appetite and urine volume were observed in all of the dosed animals

A plausible explanation is that hemin exists as a more chemically and conformationally heterogeneous ensemble: its axial chloride ligand can be readily exchanged for water/hydroxide, and the variability in central iron coordination and redox chemistry may hinder the formation of a stable, membrane-associated stacked hemin population 80

Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome