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Following an acute administration of EtOH (5 g/kg, i.p.), KO animals exhibited 30% and 50% less EtOH and AA accumulation in circulation, respectively, suggesting an increased capacity for liver EtOH and AA metabolism in KO mice

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In addition, apoptotic caspase activity can be redox-regulated by oxPTM, with procaspase-9, procaspase-3, and caspase-3 susceptible to S-glutathiolation 54

YAP1 promotes glutamine uptake and metabolism to GSH in CRPC cells We used the CRPC cell lines PC-3 and DU145 to determine whether YAP1 regulated glutamine uptake and metabolism in CRPC