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1 Introduction Breast cancer remains a significant public health problem because to its high incidence, extensive morbidity, or fatality rates, and the fact that it is the most frequent cancer in women worldwide, even though screening and therapy have made advances ( Factors such as increased life expectancy, more urbanisation, different lifestyle choices, and eventual reproductive ages are contributing to the diseases increasing prevalence, particularly in countries with low or middle incomes (LMICs) ( The upsurge of interest on natural supplements such as phytochemicals, plant extracts, and bioactive components (namely vitamins, minerals, polyphenols, flavonoids and nutraceuticals) for their potential anticarcinogenic, antioxidant, anti-inflammatory as well as immune-modulatory effects over and above conventional breast cancer management has been observed in response to the aforementioned clinical challenge

doi: 10.3390/plants6040050 131

doi: 10.1016/j.jhep.2021.09.010 139 PelaseyedT.HanssonG

3 ARA-290 also exhibits analgesic properties by targeting the TRPV1 channel, which is involved in pain sensation