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Multi-Pathway Research Focus Supports investigation of overlapping signaling systems

Youn M, Smith SM, Lee AG, H-D C, Spiteri E, Erdmann J, Galperin I, Murphy LC, Donato M, Abidi P, Bittencourt H, Lacayo NJ, Dahl G, Aftandilian C, Davis KL, Matthews JA, Kornblau SM , Huang M, Sumarsono N, Redell M, Fu CH, Chen I-M L, Alonzo TA, Eklund EA, Gotlib J, Khatri P, Sweet-Cordero A, Hijiya N, Sakamoto KM

Acetyl-CoA derived from FAO not only fuels the TCA cycle to support additional ATP production but also contributes to the synthesis of mitochondrial phospholipids such as cardiolipin, which is indispensable for maintaining inner membrane integrity and respiratory efficiency

Besides, there was a substantial correlation between hK6 levels and -Syn content in the CSF of patients with -Syn-related diseases, including PD, DLB, and PDD (Wennstrm et al., 2013)