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*Correspondence: Xiaohong Xiang [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Moreover, also the core clock component BMAL1 has been reported to bind to p53 promoter, thereby transcriptionally triggering the downstream tumor suppressor pathway 37

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Exercise improved cytochrome c levels significantly (80%) in the kidney of GK rats, while the liver showed only a mild increase in expression after exercise

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