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For instance, NRF2 levels in pulmonary epithelial and colorectal cancer cells and the rat retina remain unchanged or are reduced during hypoxia 4345 , suggesting that other transcription factors activated by hypoxia, such as nuclear factor kappa B (NF-B) and forkhead box O3 (FoxO), primarily lead to increased antioxidant protein expression levels 10

Jill Carnahan, MD Do you want to give us your framework on kind of the majority of the really sick people you see and what might be going on that bigger level