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In the RCTs, prebiotics showed similar clinical efficacy to mesalamine, and synbiotics, combined with probiotics and prebiotics, could also significantly decrease the CAI, the levels of intestinal mucosal inflammatory cytokines and fecal calprotectin, but not DAI [308,309,310,311,312]

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also helps with blood vessel flexibility and brain chemical production(8) Vitamin B9 - plays a key role in regulating homocysteine levels in the blood, thereby supporting cerebrovascular healthy people(9) Vitamin B12 - raw material for protective myelin that surrounds nerve cells, also a key player in brain energy and fighting age-related cognitive impairment(10) Herbs & Mushrooms Many of the most popular nootropic ingredients are botanical, such as herbs and mushrooms