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Am J Physiol Endocrinol Metab 299:E364E373 Youm Y-H, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, DAgostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD (2015) Ketone body -hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease

By reducing MDSC abundance, icaritin elevated CD8 + cytotoxic T cell infiltration, representing a promising adjuvant systemic agent for HCC immunotherapy [217, 218]