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28-day, ICU and in-hospital mortality The odds of 28-day mortality and in-hospital mortality was reduced in PCT guidance compared to SOC, the former being statistically significant (OR 0.84, 95% CI: 0.74, 0.95, p = 0.008 (Additional file 1: Figure S2) and OR 0.85, 95% CI: 0.66, 1.10 (Additional file 1: Figure S3), respectively)

Medically reviewed by Lauren Okafor | MD , The Frank H Netter MD School of Medicine, Loyola University Medical Center on March 12th, 2026

Abbreviations AE: Adverse event AUC 0t : Area under the plasma concentration-time curve from time zero to time AUC 0 : Area under the curve from time 0 extrapolated to infinity AUC _%Extrap : Greater than 20% extrapolation BMI: Body mass index CI: Confidence interval C max : Peak plasma concentration ECG: Electrocardiogram HPLC-MS/MS: High-performance liquid chromatographytandem mass spectrometry PK: Pharmacokinetic SAE: Serious adverse event T max : Time to reach the peak plasma concentration t 1/2 : Elimination half-life z : Elimination rate constant References Gao Q, Zhen K, Xia L, et al

MOTS-c is not FDA-approved for any human use as of June 2026