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Back to Journals Clinical, Cosmetic and Investigational Dermatology Volume 18 Geometric-Marking Quantification for First-Stage Excision of Large Congenital Melanocytic Nevi Received 30 April 2025 Accepted for publication 28 July 2025 Published 4 August 2025 Volume 2025:18 Pages 18651872 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Michela Starace Kaixi Tan, 1 Jianfei Zhang 2 1 Department of Burns and Plastic Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Peoples Republic of China

Additional information Competing interests The authors declare that they have no competing interests

Melanotan II's lactam bridge between the Asp and Lys side chains constrains the peptide into a rigid cyclic conformation that dramatically reduces the conformational entropy penalty upon receptor binding, resulting in higher binding affinity at melanocortin receptors compared to linear analogs of equivalent sequence

En el corion superficial subyacente puede haber algn melanfago, pero habitualmente no se observa infiltrado inflamatorio acompaante