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Their findings revealed a significant reduction in glucose production and expression of both G6pc and Pck1 in hepatocytes with NNMT overexpression and concurrent Sirt1 inhibition, compared to hepatocytes with NNMT overexpression alone

Hum Mol Genet 13:14071420

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In mice, feeding of a vitamin E-deficient diet (2 mg RRR-T/kg diet) for 3 months reduced, whereas RRR-T supplementation up to 9 months (200 mg/kg diet) did not alter hepatic mRNA expression of Cyp3a11 (the murine homologue of the human CYP3A4) compared with control (20 mg/kg diet) ( Reference Kluth, Landes and Pfluger 56 )