Given that diarrhea and not endotoxemia is one of the principal clinical consequences of infection with enteric toxigenic bacteria, which demonstrably affect tight junction function, one must differentiate the modest increase in paracellular permeability reported in inflammatory conditions with no known over acute clinical consequences from the marked increase in paracellular permeability induced by enteric exotoxins with consequent massive fluid and electrolyte secretion and diarrhea
Choose GHRP-2 if: You want GH stimulation without intense hunger GHRP-2's milder appetite effect makes it more practical for those who don't want to deal with powerful hunger surges You're combining with a GHRH analog Both peptides synergize equally well with CJC-1295 or Sermorelin, but GHRP-2's lower appetite impact makes the combination more comfortable You're lean and trying to stay lean Intense hunger can sabotage body composition goals You want the most studied diagnostic variant GHRP-2 has more clinical validation as a pituitary function test Choose GHRP-6 if: Appetite stimulation is a feature, not a bug Recovery from illness, post-surgery, cachexia, or deliberate caloric surplus goals benefit from GHRP-6's orexigenic effect You're interested in cytoprotective applications GHRP-6 has a more extensive literature on cardioprotection, neuroprotection, and tissue protection (GHRP-6 cardioprotection, 2024) You're underweight or struggling to eat enough The appetite boost can be therapeutic You want the historical "first" GHRP GHRP-6 has the longest research track record in the family Choose Neither (Consider Alternatives) if: You want minimal side effects Ipamorelin (most selective GHSR-1a agonist) You want maximum GH potency Hexarelin (strongest GHRP, but highest cortisol/prolactin)
FEBS Lett 1999;444(2-3):160-4
However, the evidence regarding selenium supplementation for diabetes management is mixed
