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Oxidative Medicine and Cellular Longevity, 2011 , 194586

213 Moreover, ZIP12, exclusively expressed in the CNS, plays a vital role in neuronal differentiation, including tubulin polymerization and neurite extension, by facilitating zinc uptake into the cytosol

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Thus, the R-loop-mediated replication fork stalling observed upon HRASV12 expression may be driven by ROS-induced dissociation of the TIMELESS-TIPIN complex from the replisome, resulting in replication slowdown (Fig