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N-acetyl-cysteine infusion resulted in a 26.3% increase in time to exhaustion at 92% peak VO 2

2 Methodology Relevant recent information on oxidative stress, free radicals, reactive oxidative species, and natural and synthetic antioxidants was collected by researching electronic databases such as PubMed/Medline, Web of Science, and Science Direct using the following MeSH terms: Antioxidants/analysis, Antioxidants/metabolism, Antioxidants/therapeutic use, Diet, Food Analysis, Forecasting, Free Radicals/adverse effects, Free Radicals/antagonists and inhibitors, Free Radicals/metabolism, Humans, Lipid Peroxidation/physiology, Reactive Oxygen Species/adverse effects, Reactive Oxygen Species/metabolism, Reactive Oxygen Species/therapeutic use, Antioxidants/metabolism Free Radicals/adverse effects, free Radicals/metabolism, Humans Oxidative Stress Oxygen/metabolism

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However, topical products often provide only surface-level support and are less effective than oral supplementation