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B vitamins can help the C677T version of the MTHFR protein do its job

Nevertheless, whether a specific mutation in a given gene exerts a particular biological effect, rather than functioning simply as tumor-promoting or tumor-suppressing, remains insufficiently explored

doi: 10.1371/journal.pone.0096285 82 RussellKEChungKFClarkeCJDurhamALMalliaPFootittJet al

This motion can be seen by the increase in the inter-subunit F426F426 distance from 14 (substrate-bound) to 18 (occluded) and then to 29 (outward-facing)