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Akhadov, N

Catalyzed by DNA methyltransferases (DNMT1, DNMT2, DNMT3a, DNMT3b), it involves the transfer of a methyl group from S-adenosylmethionine (SAM) to the 5 carbon position of cytosine residues, subsequently silencing gene expression by impeding transcription factor binding

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In these studies, the regulation by Pin1 required both the catalytic domain of the isomerase and the presence of a Pro immediately following the phosphorylated Thr at the turn-motif phosphorylation site, one of two C-terminal sites that are phosphorylated during the maturation of PKC isozymes (18)