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2015;10(5):e0126704

The regeneration of GSSG was slower in an ero11 mutant strain than in wildtype cells, and was faster in cells overexpressing Ero1 from a multicopy plasmid (Cuozzo & Kaiser, 1999)

In this reaction, 5-methyl-tetrahydrofolate transfers its methyl group to cobalamin (vitamin B12) to form methyl-cobalamin bound to MS and activates the enzyme 4

The main reason may be that chronic inflammation caused by SCI leads to increased expression of pro-inflammatory cytokines, stimulates the hypothalamus to secrete growth Inhibitors, inhibits the hypothalamus-GH-IGF-1 axis, and increases GH resistance