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This finding is consistent with clinical results, in which activity of sotorasib seems to be lower in colorectal cancer patients

FIN56 induces post-translational degradation of GPX4 by relying on Acetyl CoA carboxylase, which decreases GPX4 expression and ultimately leads to cell ferroptosis

Finally, cells were washed and directly observed using Laser Scanning Confocal Microscope (Zeiss LSM 510, Jena, Germany)

Over time, these deposits cause localized retinal atrophy and photoreceptor dysfunction, leading to gradual central scotomas and the need for brighter light during detailed tasks