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Abstract Evidence is emerging that dysregulation of circulating concentrations of homocysteine, an important intermediate in folate and vitamin B12 metabolism, is associated with autism spectrum disorder (ASD), but comprehensive assessments and correlations with disease characteristics have not been reported

IB is only phosphorylated by certain stimuli including LPS (lipopolysaccharide) and IL-1, whereas IB phosphorylation is triggered by most NF-B activators

Secondary BAs play a role in the modulation of immune system activity through BAs receptors, such as Takeda G-protein-coupled BAs receptor-1 (TGR5), farnesoid X receptor (FXR), pregnane X receptor (PXR), retinoid-related orphan receptor-t (RORyt), and Vitamin D receptor (VDR) [25]