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Gu R, Zhang F, Chen G, et al

doi: 10.1038/s12276-023-01077-y 133 HangauerMJViswanathanVSRyanMJBoleDEatonJKMatovAet al

29,30 Whereas the extrinsic factors influencing the skin microbiome cover many of the extrinsic photoaging items, but also include hygiene, beauty routine (cosmetics, etc.) and availability of nutrients for skin microorganisms

However, hypoxia, along with antigen stimulation, did cause T cell exhaustion, in conjunction with high levels of reactive oxygen species (ROS) from dysfunctional mitochondria