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In its registration trials it reduced visceral adipose tissue by roughly 15% over 26 weeks without a meaningful change in total body weight (PMID 20554713), and a later study confirmed reductions in visceral and liver fat in the same population (PMID 25038357)

It can also be part of a broader treatment plan that includes lifestyle modifications and physiotherapy exercises

6 The potential role of exercise-related irisin in depression 6.1 Irisin regulates energy metabolism Impaired brain energy metabolism has gained increasing attention as a key factor in the pathogenesis of depression (Wu et al., 2016

However, currently, there is insufficient information to make definitive recommendations on the vaccine type (Kass, 2018)