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Remarkably, in a study of healthy women, levels of Bacteroides , identified as the major microbial producers of GABA, were associated with increased grey matter in the cerebellum, hippocampus, and frontal regions of the brain, as well as reduced levels of anxiety, distress, and irritability (236)

Pregnant or lactating women, the chronically ill, elderly, individuals under the age of 18, those taking prescription medications (e.g., blood thinners) as well as those with a physician diagnosed medical condition should consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements

Future studies should utilize in vivo models to compare the Treg population frequency when comparing the R620W variant to an appropriate control

These effects are mediated, in part, by the positive activation of the ERK/MAPK signaling pathway (Jover-Mengual et al., 2007)