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Databases such as PubMed, Scopus, and Web of Science were utilized, employing relevant keywords related to the ME/CFS, Gut-Brain Axis, Gut Health, Intestinal Dysbiosis, Microbiome Dysbiosis, Pathophysiology, and Therapeutic Approaches. The goal was to extract qualitative and quantitative data from studies that investigate gut microbiota composition, assess inflammatory markers, and evaluate the therapeutic outcomes of interventions targeting the microbiome