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The substitution of carboxamide at the alkyl terminal (KL2, KL4 and KL5) or removal of the nitrile group from the dihydropyridine ring (KL6) moderately reduced their adjuvant activity (Extended Data Fig

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Plasma levels of total protein (TP), albumin (ALB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol (CHOL), triglycerides (TRIGL), high-density lipoproteins (HDL), low-density lipoprotein (LDL), uric acid (UA), creatinine (CREJ) and glucose (GLU) were measured using automated analyser (Cobas c111 Analyzer, Roche Diagnostics)